What is 5-Alpha Reductase?
To medical specialists, the 5-alpha reductase enzyme is easily identified as the enzyme which converts testosterone to Dihydrotestosterone or DHT which is thought to be the hormone that triggers Androgenetic alopecia in individuals who are genetically susceptible.
The 5 alpha reductase enzymes have been medically proven to convert the hormone testosterone into a super and much potent hormone that is Dihydrotestosterone. DHT is primarily the main cause of androgenetic alopecia, which is also known as the male and female pattern baldness. History stated that 5-alpha reductase enzyme was initially discovered in the prostate of most men where it modifies the conversion of the hormone testosterone into a destructive hormone dihydrotestosterone. This whole process is considerably blameful of why men endure an enlargement of the prostate and when the modification happens, the action can seemingly bind to the androgen receptor thus initiating the progressing development of the external genitalia and prostate.
In the long procedure, concerned doctors and specialists have also found out that the 5-alpha reductase enzyme can also occur in the scalp hair follicles of humans and somewhere in the area of the skin, wherein it usually disseminates equivalent reaction as in the prostate. It has been assessed that the disruption of the
5-alpha reductase activity in the skin cells may contribute to male pattern baldness
and could provide a sufficient evidence in such hair loss condition.
There are two 5-alpha reductase enzymes, the type I and the type II. They are both active in different sectors of the body and are also responsible in producing Dihydrotestosterone that can disperse throughout the body and can inevitably burst effects in other organs.
The two different types of 5-alpha reductase enzymes are individually coded by a separate gene which is generated by dissimilar and numerous tissues and the genes for 5-alpha reductase has been totally outlined to chromosome 5. However, both seem essentially significant in developing androgenetic alopecia. Studies show that the first type of 5-alpha reductase is considered to be more prominent because it is predominantly vigorous in the human scalp and hair follicles in a very high manner. The type I 5-alpha reductase enzyme abundantly produces 60% to 705 of Dihydrotestosterone in the human body while on the other hand, the type II 5-alpha reductase enzyme only produces the extra 30% to 40% of DHT in the body.
Bella Hayes
Bella a hair care expert with 6 years of solid experience in the field where she continues to draw inspiration from all her articles. She hopes to touch the lives of hair loss sufferers around the world through writing.
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